Fri Jul 25 2025

96 articles - From Friday Jul 18 2025 to Friday Jul 25 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Am J Gastroenterol

ACG Clinical Guideline Update: Preventive Care in Inflammatory Bowel Disease.

Health maintenance recommendations addressed in this guideline include the safety and appropriate timing of vaccinations, screening for osteoporosis, cervical cancer, melanoma and non-melanoma skin cancer and screening for depression, anxiety, and need for smoking cessation. To accomplish these health maintenance goals, coordination among the primary care provider, gastroenterology team, and other specialists is necessary.

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ACG Clinical Guideline Update: Ulcerative Colitis in Adults.

These guidelines represent the state of the evidence at the time of this publication. As new evidence emerges, these guidelines will be continuously reviewed, and updates will be published as needed to assure continued validity.

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ACG Clinical Guideline: Management of Crohn's Disease in Adults.

The Committee reviews guidelines in depth, with participation from experienced clinicians and others in related fields. The final recommendations are based on the data available at the time of the production of the document and may be updated with pertinent scientific developments later.

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Gastroenterology

AGA Clinical Practice Update on Incorporating Functional Lumen Imaging Probe Into Esophageal Clinical Practice: Expert Review.

BEST PRACTICE ADVICE 10: Clinicians may consider performing FLIP in the evaluation of persisting symptoms of esophageal obstruction (ie, dysphagia, esophageal-type regurgitation, and/or meal-related chest pain) after treatment of achalasia spectrum disorders. BEST PRACTICE ADVICE 11: Clinicians may consider performing FLIP in the evaluation of symptoms of esophageal obstruction after invasive foregut intervention (ie, antireflux or bariatric intervention).

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Meta-analysis

meta-analyses and systematic reviews

Am J Gastroenterol

Predominant serrated molecular signature in postcolonoscopy colorectal cancer: A systematic review and meta-analysis.

Clinical and molecular features indicate that PCCRCs are more likely to be associated with the serrated pathway than with SCRC. Enhancing the detection of clinically significant serrated lesions may improve the efficacy of CRC screening.

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Gastrointest Endosc

Clinical outcomes of EUS-guided gallbladder drainage in patients with acute cholecystitis with ≥1 year of follow-up: a systematic review and meta-analysis.

This study demonstrates that EUS-GBD is a technically effective and clinically durable treatment modality for acute cholecystitis with over one year follow up duration. The overall low rate of AEs associated with EUS-GBD reflects its unique ability to care for individuals considered high risk for surgery.

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Comparison of the safety, efficacy, and rates of GERD between full thickness versus modified per oral endoscopic myotomy for achalasia: A systematic review and Meta-Analysis.

Our analysis showed that MM POEM (the OS technique) may lead to reduction in symptomatic reflux as compared with FT POEM for achalasia. The limited number of included studies (with most of them being observational) must be considered while interpreting these findings.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Appendectomy Is Not Associated With a Milder Clinical Course of Ulcerative Colitis: A Nationwide Danish Population-Based Study.

Patients with UC who underwent appendectomy did not experience a milder clinical course compared to those without appendectomy, regardless of underlying appendicitis.

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Bradycardia and Other Arrhythmias in Patients With Hepatorenal Syndrome-Acute Kidney Injury Following Terlipressin Treatment: A Pooled Analysis of Three North American Phase III Clinical Studies.

In a pooled analysis, bradycardia was observed in 6% of terlipressin-treated patients but rarely required a dose interruption or reduction. Arrhythmia SAE incidences were low and similar in both treatment groups. Routine intensive cardiac monitoring for the detection of arrhythmias may not be necessary during terlipressin administration.

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Clinical and Genetic Associations in Cephalosporin-Induced Liver Injury: Insights From the Drug-Induced Liver Injury Network.

Cephalosporins can cause self-limited, mixed/cholestatic hepatitis that arises after a short course of therapy with a latency of up to 3 weeks with cefazolin. Cephalosporin-induced liver injury is associated with the HLA-A*02 01 allele, which is linked to more severe liver injury at the onset of illness.

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Outcome After Surgery for Colon Cancer in a National Cohort of Patients With and Without Inflammatory Bowel Disease.

Inflammatory bowel disease negatively influences the prognosis of colon cancer. Proctocolectomy was performed only in a minority of those with inflammatory bowel disease. Outcomes need to be improved in patients with inflammatory bowel disease developing colon cancer.

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Persistent Binge Drinking History Associated With Advanced Liver Fibrosis and All-Cause Mortality in MetALD.

PBD history is associated with increased risks of advanced fibrosis and mortality in MetALD. Clinical assessment should include an evaluation of drinking patterns and history, particularly persistent binge drinking.

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Primary Sclerosing Cholangitis in the Absence of Inflammatory Bowel Disease Increases the Risk of Colorectal Cancer: A Multi-Centre Propensity Score Matched Analysis.

Our findings provide real-world evidence that PSC is an independent risk factor for colorectal cancer, even in the absence of concomitant IBD. These results support the need for further research to determine whether patients with isolated PSC may benefit from tailored CRC surveillance strategies.

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Am J Gastroenterol

A comparison of the predictive value of 12 body composition markers for MASLD, at-risk MASH and increased liver stiffness in a general population setting.

In the general population, MASLD and MASH risk increased even when WC 100 cm. Although relatively minor differences, WC consistently demonstrated the highest predictive value for MASLD, at-risk MASH, and increased LSM and therefore most suited for MASLD diagnosis, management and risk stratification.

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Efficacy and safety of carvedilol in cirrhosis patients with new-onset uncomplicated ascites without high-risk esophageal varices. (CARVE-AS Trial).

Administration of carvedilol in patients with cirrhosis with new-onset uncomplicated ascites without high-risk varices is safe and prevents further ascites-related complications, with reduced need for large volume paracentesis and improved survival.

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Risk factor profiles and elevated incidence of pancreatic cancer in Native Hawaiians.

Notably, Native Hawaiian males with ≥2 risk factors had >5 times the risk relative to White males with no risk factors. This study emphasizes the need for targeted prevention and screening for this underserved population.

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Thiopurines and intrahepatic cholestasis of pregnancy in systemic lupus erythematosus and inflammatory bowel disease pregnancies.

In SLE and IBD, thiopurine exposure during pregnancy was associated with an increased risk of ICP, regardless of ICP history, hypertension, renal diseases, liver diseases, and glucocorticoid use.

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Clin Gastroenterol Hepatol

Development and external validation of an endoscopic and histologic pouchitis assessment tool: the Atlantic Pouchitis Index.

Development and validation of the API advances pouchitis disease assessment. Integration of endoscopy and histopathology results in an objective, reliable, and responsive instrument to evaluate therapy effectiveness in research and clinical settings.

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Distribution of Esophageal Eosinophilia as a Predictor of Proton Pump Inhibitor Response in Eosinophilic Esophagitis.

Isolated distal eosinophilia at index endoscopy independently predicted PPI response in EoE, while proximal-predominant pattern predicted non-response. Patterns of esophageal eosinophilic distribution may reflect different disease phenotypes and help guide management.

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Impact of inflammatory bowel disease and primary sclerosing cholangitis on colorectal cancer risk:national cohort study.

IBD patients have an increased risk of CRC, mostly prominent among young PSC+ patients. PSC+ patients display a tendency to develop CRC in the proximal colon and more synchronous CRC. This should be considered when monitoring and counselling IBD patients.

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Lumen-Apposing Stents with or without Pigtail in Endosonography-Guided Biliary Drainage for Malignant Distal Biliary Obstruction.

In patients with malignant distal biliary obstruction, EUS-guided biliary drainage using LAMS with coaxial DPS was superior to LAMS alone. It offered clinical benefits including lower recurrent biliary obstruction rate and shorter hospitalization (ClinicalTrials.gov, number NCT04595058).

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Multi-Center Validation of Video-Based Deep Learning to Evaluate Defecation Patterns on 3D High-Definition Anorectal Manometry.

3D high-definition anorectal manometry combined with video-based deep learning is a useful and clinically relevant technology for evaluating anorectal dyssynergia. Future use cases can be expanded to evaluating other motility disorders and their treatment.

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The Real-World Impact of Vitamin D Supplementation on Inflammatory Bowel Disease Clinical Outcomes.

Vitamin D supplementation was associated with reduced IBD-related ED visits, hospitalizations, and corticosteroid use, supporting its potential as a low-cost adjunct in IBD management. Prospective studies are needed to optimize dosing strategies and define target serum levels for improved long-term outcomes.

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Endoscopy

Artificial intelligence for endoscopic grading of gastric intestinal metaplasia: advancing risk stratification for gastric cancer.

We demonstrated the potential of applying AI tools in endoscopic image analyses, by estimating EGGIM with high accuracy. This opens the possibility for automated assessment of EGGIM, providing a greener strategy for gastric cancer risk stratification but also for prospective studies and interventional trials.

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Computer-assisted optical diagnosis of colorectal polyps up to 10mm.

In our study, CADx-assisted diagnosis met the resect-and-discard PIVI1 threshold only for diagnosis of polyps up to 3mm and the diagnose-and-leave PIVI2 threshold for polyps up to 10mm.

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Endoscopic ultrasound-guided gallbladder versus bile duct drainage for first-line therapy of malignant biliary obstruction: international multicenter trial.

Our study showed that in patients with distal MBO, the use of EUS-GBD or EUS-CDS were comparable, with similar rates of efficacy and safety. EUS-GBD could represent an easy and safe option in patients with DMBO without previous cholecystectomy and with clear patency of the cystic duct.

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Long-term impact of computer-aided adenoma detection: a prospective observational study.

After CADe implementation, detection rate in procedures performed without CADe was maintained and did not decline.

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The effect of prophylactic clipping on delayed bleeding after proximal colonic endoscopic mucosal resection: a multicenter, randomized controlled trial (CLIPPER).

Prophylactic clipping did not reduce delayed bleeding in patients undergoing EMR for large laterally spreading and sessile polyps in the proximal colon in daily clinical practice.

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Gastroenterology

Early infliximab levels and clearance predict outcomes after infliximab rescue in acute severe ulcerative colitis: Results from PREDICT-UC.

Early infliximab levels and clearance calculation can predict outcomes in ASUC. This is the first study to demonstrate that high infliximab clearance may be overcome by intensified infliximab dosing.

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The natural history of gastroesophageal varices in children with portal hypertension.

Worsening of the endoscopic pattern is common in children with portal hypertension. HRV can be expected to emerge in one-third and one-half of initially HRV-negative children after 5 and 10 years, respectively. Infants with biliary atresia are at particularly high risk. These findings support the rationale for considering primary prophylaxis of bleeding.

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Gastrointest Endosc

Clinical Outcomes of Endoscopic Submucosal Dissection for Residual Neoplasia After Incomplete Resection of Large Non-Pedunculated Colorectal Polyps: A Large Multicenter Propensity Match Study.

ESD can be performed safely and effectively as a salvage therapy after failed attempt at ER of LNPCPs. ESD may be selectively considered as part of our endoscopic armamentarium for the management of these difficult-to-treat lesions. support current guideline endorsed indications for ESD for the treatment of residual neoplasia after incomplete ER.

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One-year survival rate of unresectable pancreatic cancer size smaller than 4 cm treated with or without EUS-RFA.

EUS-RFA as an adjunct for UPDAC ≤ 4 cm may improve survival with minimal side effects.

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Gut

Hybrid identity and distinct methylation profiles of incomplete intestinal metaplasia in the stomach.

Inc IM represents a phenotypically unstable and epigenetically deregulated metaplastic state with dual-lineage potential and molecular resemblance to GC. These findings establish Inc IM as a true precursor to GC and underscore the importance of active surveillance and early intervention strategies.

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Insulin-like peptide 5 is released in response to bile acid in the rectum and is associated with diarrhoea severity in patients with bile acid diarrhoea.

The study highlights that rectal bile acids stimulate INSL5 secretion in humans, and that INSL5 levels are associated with a colonic pro-motility response and pathophysiology of chronic diarrhoea.

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Mitochondrial dysfunction drives basal cell hyperplasia in eosinophilic oesophagitis.

Further, omeprazole alleviated mitochondrial damage and dysfunction in EoE-related BCH modelled in mice and patient-derived organoids. CONCLUSION: Mitochondrial dysfunction is tightly linked to perturbation of redox homeostasis in EoE-related BCH, which is promoted by IL-13 and reversible with omeprazole treatment.

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Pericyte drives the formation of circulating tumour cell-neutrophil clusters to promote colorectal cancer metastasis.

This study uncovers the previously undefined location and mechanism of CTC-neutrophil cluster formation and underscores the potential of pericyte-driven CTC-neutrophil clusters as a valuable prognostic indicator and therapeutic target for CRC metastasis.

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Targeting Treg-fibroblast interaction to enhance immunotherapy in steatotic liver disease-related hepatocellular carcinoma.

This study uncovers critical immune and metabolic adaptations in SLD-HCC, identifying TNFSF14-TNFRSF14 signalling as a key driver of immunotherapy resistance. Targeting this signalling axis enhances antitumour immunity and improves immunotherapy efficacy, offering a promising therapeutic strategy for SLD-HCC.

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Hepatology

Causes of mortality among patients with early-stage hepatocellular carcinoma.

Cause of death varies among patients with early-stage HCC, although HCC-related death remains the most common cause. Efforts are needed to optimize curative treatment effectiveness among patients with early-stage HCC to reduce cancer-related mortality.

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Distinctive hemodynamic phenotype in Fontan-type circulation patients with distal esophageal varices.

Distal EV are frequent and characterize a distinct hemodynamic phenotype, featuring elevated Fontan pathway pressures, severe hepatic fibrosis, portal hypertension, and a hyperdynamic circulatory state.

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NEK7 induced phosphorylation of EGFR on serine 1070 drive the acquired lenvatinib resistance in hepatocellular carcinoma.

Our results unveil insights into the acquired lenvatinib resistance mechanism that NEK7 phosphorylates EGFR at S1070 to promote acquired lenvatinib resistance in HCC.

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J Hepatol

B cells drive CCR5<sup>+</sup>CD4<sup>+</sup> tissue-resident memory T cell cytotoxicity via IL-15Rα-IL-15 signaling in primary biliary cholangitis.

Impact and implications This study reveals that IL-15Rα-expressing B cells manifest a pro-inflammatory phenotype and promote biliary injury by impairing immune homeostasis through aberrant activation of tissue-resident memory T cells during PBC progression. Although we now offer a new paradigm how IL-15 trans-presentation is regulated in a B cell-dependent manner in PBC, the regulatory effects of IL-15Rα/IL-15 signaling on other chronic liver diseases remain to be further elucidated.

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Restoration of N-glycosylation via leucine-activated leucyl-tRNA synthetase 1 overcomes chemoresistance in intrahepatic cholangiocarcinoma.

This study uncovers a novel mechanism of LARS1-dependent codon-biased translation underling ICC chemoresistance. It further establishes leucine supplementation as a feasible, and potentially translational strategy to improve the efficacy of ICC chemotherapy. Impact and implications This study demonstrates that LARS1 downregulation disrupts N-glycan biosynthesis and enhances ABCC1-mediated chemoresistance in ICC. Our findings are important for oncologists and translational researchers, as they identify LARS1-dependent codon-biased translation as a critical determinant of chemotherapy response in ICC. Practically, we uncover that exogenous leucine supplementation restores LARS1 levels and synergises with gemcitabine-oxaliplatin treatment, offering a safe dietary intervention to overcome chemoresistance. These implications are firmly based on preclinical evidence, although future clinical trials are needed to validate the safety and efficacy of leucine supplementation strategies in ICC patients.

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Rivaroxaban to prevent complications of portal hypertension in cirrhosis: The CIRROXABAN study.

In cirrhotic patients with moderate liver dysfunction, rivaroxaban may improve PHT complication-free survival without significantly increasing major bleeding events. Impact and implications This study provides novel evidence of the potential use of rivaroxaban to prevent liver decompensation in cirrhotic patients with portal hypertension. The observed reduction in decompensation events aligns with previous findings on anticoagulation in cirrhosis, suggesting a potential therapeutic role for rivaroxaban in this population. Although the reduction of the primary endpoint did not reach statistical significance in the whole cohort, this potential effect was observed in a post hoc analysis in Child-Pugh B patients; however, these findings should be interpreted with caution due to the exploratory and post hoc nature of the subgroup analyses. Non portal hypertension related bleeding was overall increased in patients receiving rivaroxaban but not those that were classified as severe. These findings underscore the need for further investigation into optimal dosing strategies to maximize efficacy while minimizing bleeding risks.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial on 'Prevalence and Predictors of Symptoms of Anxiety or Depression at Diagnosis in Patients With Inflammatory Bowel Disease: An Inception Cohort'.

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Editorial: Polypharmacy in MASLD-An Overlooked Epidemic Disproportionately Affecting Women and Patients With Cirrhosis.

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Clin Gastroenterol Hepatol

Addressing Gaps in Colorectal Cancer Screening: The Role of Patient Navigation and Future Directions.

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Advancing Inflammatory Bowel Disease-driven Colorectal Cancer Management: Molecular Insights and Endoscopic Breakthroughs Towards Precision Medicine.

The future of IBD-related CRC management will incorporate a holistic, multi-integrated approach, combining AI-driven diagnostics, omics data integration, endoscopic and surgical innovations and nanotechnology-based therapies. This paradigm shift aims to enhance precision medicine, promoting organ-sparing approaches, improved diagnostics, and personalized cancer treatment with the potential to reduce CRC risk.

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MASLD in Patients with Chronic Hepatitis B Virus Infection: Hiding in Plain Sight.

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Management of the Disconnected Pancreatic Duct in Pancreatic Necrosis.

The 7 questions followed by recommendations included the appropriate definition for the syndromes, the radiographic definition for diagnosis; the appropriate timing for evaluation for diagnosis; the ideal diagnostic method; the use of pancreatic duct stents in this syndrome; the utility and safety of double plastic stents following endoscopic transmural drainage, and the role of surgical therapy. Important diagnostic and therapeutic questions were derived which should be useful for the management of these patients as well as important research questions going forward.

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Gastroenterology

Rethinking Nutrition in IBD: The Case for a Whole Food Approach.

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Gut

Non-invasive tests of fibrosis in the management of MASLD: revolutionising diagnosis, progression and regression monitoring.

We suggest that future studies prioritise the validation of NITs across diverse ethnic populations. We believe it essential to explore the role of NITs in dynamic monitoring and integration of multiomics technologies, artificial intelligence and personalised risk models to improve diagnostic accuracy and treatment planning.

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Recent advances in clinical practice endohepatology: the endoscopic liver rush.

These involve, among others, endoscopic ultrasound (EUS)-guided liver biopsy, EUS-guided portal pressure gradient measurement, coil and glue embolisation of gastric varices and spontaneous portosystemic shunts, artificial-assisted cholangioscopy. In this review, we aim to focus on different applications within endohepatology which are at the benchtop (or coming close by) and attempt to prognosticate potential future techniques within this rapidly evolving field.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Response to Liao and Lai.

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Clin Gastroenterol Hepatol

A Meta-Epidemiological Analysis of Sex Disparities in Hepatology Clinical Trials.

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Artificial Intelligence and Endoscopist Diagnostic Agreement as a Framework for Colorectal Polyp Optical Diagnosis Implementation.

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ChatGPT Is Not Yet Ready to Replace Motility Experts.

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Distension-mediated obstruction, a novel pathophysiology in functional dysphagia.

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Outcomes of Tumor-Based Universal Screening for Lynch Syndrome in Patients with Colorectal Cancer in a Large U.S. Population.

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Endoscopy

Complication of endoscopic vacuum therapy in anastomotic leak: closure of iatrogenic small bowel fistula using a novel helix tacking device.

Pubmed   Journal   ReadQx   PMC

Distensibility measurement in the selection of patients for endoscopic pyloromyotomy: promising and logical, but still not ready for prime time.

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Loop-tipped guidewire-assisted cannulation of disposable imaging catheter into appendiceal lumen for difficult endoscopic retrograde appendicitis therapy.

Pubmed   Journal   ReadQx   PMC

Novel underwater endoscopic submucosal dissection system employing two flushing pumps to provide a clear field of view: the paired pump immersion system.

Pubmed   Journal   ReadQx   PMC

Usefulness of bilateral traction method for endoscopic submucosal dissection of superficial pharyngeal cancer.

Pubmed   Journal   ReadQx   PMC

Gastroenterology

Early-life colibactin exposure is associated with early-onset colorectal cancer occurrence.

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Gender Equity in Gastroenterology: Perspectives From the AGA Women's Committee on Current Frameworks and Future Directions.

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Mild Crohn's Disease is Associated with Altered Sphingolipid Metabolism and Reduced Neutrophilic Inflammation.

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Novel Insights Into the Progression of α1-Antitrypsin Deficiency-Associated Liver Disease Using Artificial Intelligence-Driven Deep Visual Proteomics.

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Risk-adapted starting ages for colorectal cancer screening based on comprehensive family history.

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Unraveling the genetic mosaic of congenital enteropathies.

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Gastrointest Endosc

Endoscopic ultrasound-guided enteroscopic treatment for small-bowel stricture with enteroscope (with video).

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Single Session Real-Time Diagnosis and Treatment of Branch-duct Intraductal Papillary Mucinous Neoplasms.

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Top Tips for the Diagnosis of Celiac Disease.

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Gut

Hepatocyte senescence in alcohol-associated hepatitis: epiphenomenon or disease-driving mechanism?

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How accurate is EUS-guided direct portal vein pressure measurement? A comparison with intraoperative measurements.

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New frontier in albumin replacement therapy.

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New look on oats in coeliac disease.

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Hepatology

2D-SWE in MASLD: Should we utilize it more with these new cutoffs?

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Better late than resectable: Combination therapy finds its moment.

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Decoding liver risk: A deep dive into the Baveno VII "Rule-of-Five" criteria.

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Deep learning's crystal ball: Predicting HCC surgery success with multimodal imaging.

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Letter to the Editor: Can we assess the diagnostic accuracy of 2D-SWE for liver fibrosis staging in MASLD?

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Minor players, major signals: Unveiling the systemic and gut-localized impact of microbial amidated bile acids in hepatopancreatobiliary disease.

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Reply: Considerations on the diagnostic accuracy and applicability of MASHResInd in MASH Resolution.

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Unraveling the metabolic thread: Type 2 diabetes and fibrosis in chronic hepatitis B with steatosis.

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J Hepatol

From the Editor's Desk...

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial on 'Prevalence and Predictors of Symptoms of Anxiety or Depression at Diagnosis in Patients With Inflammatory Bowel Disease: An Inception Cohort'. Authors' Reply.

Pubmed   Journal   ReadQx 

Editorial: JAK to JAK-Navigating Intra-Class JAK Inhibitor Switching in Inflammatory Bowel Disease. Authors' Reply.

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Letter: H. pylori Infection May Constitute a Risk Factor for Reflux Disease and Colonic Neoplasia-Authors' Reply.

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Letter: H. pylori Infection May Constitute a Risk Factor for Reflux Disease and Colonic Neoplasia.

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Gastroenterology

Beyond County Boundaries: Rethinking Gastroenterology Access Metrics in the United States.

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Further dimensions of the role of TREM2 in pancreatic ductal adenocarcinoma.

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Gut

Anticoagulation in colorectal ESD: implications for bleeding risk management.

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Balancing safety and recurrence: pooled analysis of cold snare EMR for large colorectal polyps.

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Endoscopic intermuscular dissection for rectal cancer: are we ready to skip surgery?

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Rethinking 'Inactive Chronic Hepatitis B': should we treat patients with high HBsAg levels?

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Statin use association with all-cause mortality and liver-related outcomes: are the benefits true?

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